The pregnane x receptor

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August undefined, 2024

Webb2006 Orphan nuclear receptor pregnane X receptor sen-sitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 20:279–290 24. Curnow KM, … WebbMicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor Jiaqi Li,1,2 Jing Zhao,2 Huan Wang,2 Xiaohan Li,2 …

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross …

WebbEl receptor X de pregnano (PXR), también conocido como NR1I2 (de sus siglas en inglés "nuclear receptor subfamily 1, group I, ... MeSH: pregnane+X+receptor (en inglés) Datos: … population of hervey bay 2021

The pregnane X receptor regulates gene expression in a ligand

プレグナンX受容体（プレグナンXじゅようたい、英: pregnane X receptor、略称: PXR）は、ヒトではNR1I2遺伝子によってコードされるタンパク質である。SXR（steroid and xenobiotic sensing nuclear receptor）、NR1I2（nuclear receptor subfamily 1, group I, member 2）の名称でも知られる。 WebbThe pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals. PXR is activated by a structurally diverse … Webb1 feb. 2024 · The pregnane X receptor (PXR) is a nuclear receptor which regulates drug metabolizing enzymes (DMEs) by activation from endogenous, as well as exogenous, … sharlene wallace harp

The potential use of the pregnane X receptor in cardiovascular …

Pregnane X receptor (PXR) - A contributor to the diabetes …

Webb1 apr. 2024 · Background. The pregnane X receptor (PXR) is a xenobiotic sensing nuclear receptor that is activated by a diverse array of substances, including environmental … Webb30 juni 2024 · Pregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is … sharlene wallaceWebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and Vascular Biology has examined the potential for PXR to regulate hepatic apoA-I and HDL formation in response to bileacids.12 Wild-typemice,miceinwhichthePXRgenehad population of hesston ks

"Webb13 mars 2024 · Nuclear factor erythroid 2-related factor 2 (Nrf2) and pregnane X receptor (PXR) are important transcriptional factors that regulate the expression of anti-genotoxic phase II detoxification enzymes and phase III transporters [ 18, 19, 21, 22, 23 ]. " - The pregnane x receptor

The pregnane x receptor

Diagnostics Free Full-Text High Pregnane X Receptor (PXR ...

Webb10 jan. 2014 · Financial & competing interests disclosure. The authors wish to thank the British Heart Foundation (BS/02/002), the Wellcome Trust (074361/Z/04/Z) and Barts … Webb12 maj 2024 · The nuclear pregnane X receptor protects against bilateral renal ischemia/reperfusion-induced acute kidney injury in mice. Response to comment on …

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Webb24 sep. 2024 · The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with high levels of expression in the liver. It not only plays a key role … WebbPregnane X receptor (NR1I2) is a broad-specificity sensor playing a critical role in the regulation of phase I oxidative enzymes, phase II conjugating enzymes, and phase III …

Webb13 juni 2000 · We and others recently described a new member of the steroid/thyroid hormone receptor family, termed the pregnane X receptor (PXR), that serves as a key … Webb29 sep. 2014 · Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Low PXR expression has been shown to promote tumor initiation and metastasis. The aim of the current study was to …

Webb18 apr. 2016 · The nuclear xenobiotic pregnane X receptor (PXR) is well established as a transcriptional regulator of phase I and phase II drug-metabolizing enzymes and drug … WebbPregnane X Receptor (PXR), a member of the nuclear receptor (NR) superfamily, discovered in 1998 , represents a modular protein sharing common regions, a highly …

WebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and …

WebbPregnane X receptor (PXR, NR1I2) is activated by various chemically unrelated compounds, including environmental pollutants and drugs. We proceeded here to in vitro screening of … population of heyburn idahoWebbPregnane X receptor is a ligand-activated nuclear receptor (NR) that mainly controls inducible expression of xenobiotics handling genes including biotransformation … sharlene weightmanWebbThe nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic substances including foreign chemicals … sharlene weatherwaxWebbThe pregnane X-receptor (PXR) and the constitutive androstane receptor (CAR) are orphan nuclear receptors activated by a variety of ligands ( Kretschmer and Baldwin, 2005 ). … population of heyworth illinoisWebb1 nov. 2006 · The pregnane X receptor (PXR) is a major chemical sensor known to activate the expression of CYP3A/Cyp3a in humans and rodents. The purpose of this study is to … sharlene wattsWebbRecent studies have revealed that pregnane X receptor (PXR) can function as a master regulator to control the expression of phase I and phase II drug-metabolizing enzymes, … sharlene weaver-greaves chicago entainerWebb28 juni 2013 · Using tissue microarray analyses, we studied 62 pathology specimens for expression of pregnane xenobiotic receptor, multi-drug … sharlene watson np