Cisplatin renal function

Author: vscg

August undefined, 2024

WebApr 14, 2024 · Nicotinamide deficiency has been linked to the damage of the renal tubular cells, especially proximal tubular cells. For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [ 29, 30 ]. WebIn general, any patient with a GFR70 mL/min should be highlighted as ‘at risk’ from cisplatin renal toxicity. Kintzel PE, Dorr RT. Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function. Cancer Treat Rev. 1995; 21: 33–64GFR (mL/min) Dose60 100%50–60 75%40–50 50%40 AvoidBennett 50 100%10–50 75%

National Center for Biotechnology Information

WebMar 20, 2024 · The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to investigate the … WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … reachup

Cisplatin nephrotoxicity - UpToDate

WebMar 2, 2024 · Cisplatin is a potent anticancer drug widely used for the treatment of several malignant tumors. One of the most relevant side effects of cisplatin is nephrotoxicity, that is very well-known since its introduction in 1978 and limits its use and efficacy [ 1, 2 ]. WebRenal salt wasting syndrome has been reported in up to 10% of patients, manifesting as hyponatremia and severe ortho-static hypotension in the setting of high urinary … WebSep 1, 2024 · Cisplatin induces multiple intracellular injury pathways, including inflammation, oxidative stress, apoptotic pathways, and DNA damage mediating renal tubular cell injury. reachus experient.ph

Cisplatin - Drug Information - Chemocare

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin …

WebCisplatin, which is used as part of chemotherapeutic regimens for a wide array of different cancers, can cause acute kidney injury in 20–30% of cases. Cisplatin-induced nephrotoxicity is due to mitochondrial damage that is a consequence of increases in mitochondrial reactive oxygen species. Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths injectable... how to start a vending companyWebCisplatin is the first choice treatment in mediastinal germ cell tumors. However, concerns regarding increased toxicity of cisplatin hamper its administration in patients with impaired renal function. how to start a vending business with no money

"WebWhat Cisplatin Is Used For: Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer. Testicular, ovarian, bladder, head and neck, … " - Cisplatin renal function

Cisplatin renal function

National Center for Biotechnology Information

WebFeb 23, 2024 · Cisplatin-based neoadjuvant chemotherapy is the standard of care for patients with muscle-invasive bladder cancer (MIBC). It yields a 30% to 40% pathologic … WebApr 9, 2024 · The most common reason for cisplatin-ineligibility is renal function impairment. Up to 40% of patients with bladder cancer have renal impairment, defined …

Did you know?

WebCisplatin is the first choice treatment in mediastinal germ cell tumors. However, concerns regarding increased toxicity of cisplatin hamper its administration in patients with … WebRenal function of cancer patients "fit" for Cisplatin chemotherapy: physician perspective Authors J Montoya 1 , H G Luna 2 , J R Amparo 2 , C Casasola 3 , G Cristal-Luna 2 Affiliations 1 Joey Montoya, MD, National …

WebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic … WebJan 11, 2024 · During and after cisplatin treatment. Renal function should be closely monitored before each dose of chemotherapy every 1–2 weeks.

WebMar 23, 2024 · Histologic evaluation and blood urea nitrogen (BUN) confirmed that renal structure and function were preserved 48 h after cisplatin injury. Similarly, weight loss was slowed down. WebAbstract Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney …

WebNephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate …

reachus indusind emailWebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has been focused on cisplatin-induced acute kidney disease, whereas the mechanism of chronic kidney disease after cisplatin chemotherapy is largely unknown. In the present … how to start a vegetable garden at homeWebMar 13, 2024 · Background. Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the … reachus flytetyme.comWebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. The alleviation or prevention of CDDP … how to start a vending machine business bookWebJan 1, 2024 · Cisplatin can enter the renal tubular cells by either passive diffusion or active transport. Previous studies have indicated that movement of cisplatin through the renal … reachus appWebAug 22, 2015 · Cisplatin has a well-established role in the treatment of broad spectrum of malignancies; however its use is limited because of cisplatin-induced nephrotoxicity (CIN) which can be progressive in more than 50% of cases. reachusaWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … reachus indusindbank.com